Preconditioning in the Neonatal and Pediatric Heart

Service: Trial Number:
Principal Investigator: Conducted at:
Long Beach Memorial, Miller Children`s & Women`s Hospital Long Beach
Currently enrolling additional patients:
Age Range:
Neonates and pediatric patients
Male & Female

In this study tissue from infants and children is used to evaluate how best to enhance cardioplegia, the solution that quiets the heart during cardiac surgery. Preconditioning is a phenomenon in which cells protect themselves from a lack of oxygen and nutrients, which can occur during open heart surgery. In order to perform surgery on a congenital heart, the beating needs to be stopped and the heart opened.  There are various techniques used to protect the heart during this time but there is always some damage that is done, even if not clinically evident. This has been well studied in the adult heart but less so in the pediatric population.  The heart cells naturally protect themselves from this damage. These protective mechanisms are produced by the cells themselves. The investigators are interested in comparing these processes in adult and pediatric heart cells in the lab. The preconditioning will be able to be tested by performing a series of specific studies. The goal will be to determine the similarities and differences between the hearts of adults and the pediatric population (neonates and children). Cardiac tissue which is normally discarded during a congenital operation will be collected after consent and tested in a lab. There is no experimental procedure directly involving the patient. Adult tissue will also be collected at another center to compare the samples. This data will serve as a pilot study. This study has not been performed before. The goal is that we can find a way to allow pediatric hearts to be better protected during times of extreme stress.